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A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.

H E Mulcahy, J Lyautey, C Lederrey, X qi Chen, P Anker, E M Alstead, A Ballinger, M J Farthing and M Stroun
H E Mulcahy
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J Lyautey
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C Lederrey
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X qi Chen
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P Anker
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E M Alstead
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A Ballinger
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M J Farthing
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M Stroun
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DOI:  Published February 1998
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Abstract

K-ras mutations are frequently found in primary pancreatic adenocarcinomas. In this prospective study, we looked for K-ras mutations in the plasma of patients with pancreatic cancer. We isolated plasma DNA from 21 pancreatic cancer patients using a simple and rapid extraction technique and detected K-ras alterations with a PCR assay and subsequent product sequencing. Patients were followed up to determine their clinical outcome. We found K-ras mutations in the plasma of 17 patients (81%). In cases in which both plasma and pancreatic tissue were available, DNA mutations were similar in corresponding plasma and tissue samples. Plasma DNA alterations were found 5-14 months before clinical diagnosis in four patients. Mutant DNA was not found in the plasma of two patients with chronic pancreatitis or in five healthy controls. Our results indicate that K-ras mutations are often found in DNA isolated from the plasma of pancreatic cancer patients and that a noninvasive plasma-based assay may provide qualitative diagnostic information to clinicians in the future. Larger studies are required to further assess the relevance of our findings to clinical practice.

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February 1998
Volume 4, Issue 2
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A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.
H E Mulcahy, J Lyautey, C Lederrey, X qi Chen, P Anker, E M Alstead, A Ballinger, M J Farthing and M Stroun
Clin Cancer Res February 1 1998 (4) (2) 271-275;

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A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.
H E Mulcahy, J Lyautey, C Lederrey, X qi Chen, P Anker, E M Alstead, A Ballinger, M J Farthing and M Stroun
Clin Cancer Res February 1 1998 (4) (2) 271-275;
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Clinical Cancer Research
eISSN: 1557-3265
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