Clinical Cancer Research: 6 (12)

The Biology Behind...

The Biology Behind...

Protease Inhibitors in Oral Carcinogenesis and Chemoprevention

Scott M. Lippman and Lynn M. Matrisian

Clin Cancer Res December 1 2000 6 (12) 4599-4603;

Editorials

Editorials

Angiogenesis and Lung Cancer: Potential for Therapy

Roy S. Herbst and Isaiah J. Fidler

Clin Cancer Res December 1 2000 6 (12) 4604-4606;

Editorial

Editorial

On Receptor Inhibitors and Chemotherapy

Paula D. Ryan and Bruce A. Chabner

Clin Cancer Res December 1 2000 6 (12) 4607-4609;

Advances in Brief

Advances in Brief

Paclitaxel-induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration: Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment

W. Fraser Symmans, Matthew D. Volm, Richard L. Shapiro, A. Bridget Perkins, Alice Y. Kim, Sandra Demaria, Herman T. Yee, Heather McMullen, Ruth Oratz, Paula Klein, Silvia C. Formenti and Franco Muggia

Clin Cancer Res December 1 2000 6 (12) 4610-4617;
Advances in Brief

MDR1 Gene Overexpression and Altered Degree of Methylation at the Promoter Region in Bladder Cancer during Chemotherapeutic Treatment

Yasuhiro Tada, Morimasa Wada, Kentaro Kuroiwa, Naoko Kinugawa, Taishi Harada, Jun Nagayama, Masayuki Nakagawa, Seiji Naito and Michihiko Kuwano

Clin Cancer Res December 1 2000 6 (12) 4618-4627;
Advances in Brief

Serum Endostatin Levels Are Elevated and Correlate with Serum Vascular Endothelial Growth Factor Levels in Patients with Stage IV Clear Cell Renal Cancer

Andrew L. Feldman, Lawrence Tamarkin, Giulio F. Paciotti, Byron W. Simpson, W. Marston Linehan, James C. Yang, William E. Fogler, Ewa M. Turner, H. Richard Alexander Jr. and Steven K. Libutti

Clin Cancer Res December 1 2000 6 (12) 4628-4634;
Advances in Brief

Expression of Cytoplasmic Galectin-3 as a Prognostic Marker in Tongue Carcinoma

Yuichiro Honjo, Hidenori Inohara, Shiro Akahani, Tadashi Yoshii, Yukinori Takenaka, Jun-ichi Yoshida, Kenji Hattori, Yoichiro Tomiyama, Avraham Raz and Takeshi Kubo

Clin Cancer Res December 1 2000 6 (12) 4635-4640;
Advances in Brief

Detection of Germ-Cell Tumor Cells in Peripheral Blood Progenitor Cell Harvests: Impact on Clinical Outcome

Martin Hildebrandt, Oliver Rick, Abdulgabar Salama, Wolfgang Siegert, Dieter Huhn and Jörg Beyer

Clin Cancer Res December 1 2000 6 (12) 4641-4646;
Advances in Brief

8pter–p23 Deletion Is Associated with Racial Differences in Prostate Cancer Outcome

Joseph G. Washburn, Kirk J. Wojno, Jyotirmoy Dey, Isaac J. Powell and Jill A. Macoska

Clin Cancer Res December 1 2000 6 (12) 4647-4652;
Advances in Brief

Expression of Metastases-associated Genes in Cervical Cancers Resected in the Proliferative and Secretory Phases of the Menstrual Cycle

Silvia Formenti, Juan Felix, Dennis Salonga, Kathy Danenberg, Malcolm C. Pike and Peter Danenberg

Clin Cancer Res December 1 2000 6 (12) 4653-4657;

Clinical Trials

Clinical Trials

Vaccination with a Bivalent G_M2 and G_D2 Ganglioside Conjugate Vaccine: A Trial Comparing Doses of G_D2-Keyhole Limpet Hemocyanin

Paul B. Chapman, Donna Morrisey, Katherine S. Panageas, Linda Williams, Jonathan J. Lewis, Robert J. Israel, W. Bradley Hamilton and Philip O. Livingston

Clin Cancer Res December 1 2000 6 (12) 4658-4662;
Clinical Trials

Locoregional Cellular Immunotherapy for Patients with Advanced Esophageal Cancer

Uhi Toh, Hideaki Yamana, Susumu Sueyoshi, Toshiaki Tanaka, Fumihiko Niiya, Katsuko Katagiri, Hiromasa Fujita, Kazuo Shirozou and Kyogo Itoh

Clin Cancer Res December 1 2000 6 (12) 4663-4673;
Clinical Trials

Phase I Clinical Trial of the Chimeric Monoclonal Antibody (c30.6) in Patients with Metastatic Colorectal Cancer

Robyn L. Ward, Deborah Packham, Anne M. Smythe, Jayne Murray, Peter Anderson-Stewart, Neil Kitchen, Rosyln Muirhead, Peter Phillips, Peter Gray, Grant Bigg-Wither, Krishnan Prabakaran, Judy Freund, Michael Fullham, Michele Rule, David Dalley, Alan Meagher, Nicholas J. Hawkins and Glenn M. Smith

Clin Cancer Res December 1 2000 6 (12) 4674-4683;
Clinical Trials

Clinical Modulation of Oral Leukoplakia and Protease Activity by Bowman-Birk Inhibitor Concentrate in a Phase IIa Chemoprevention Trial

William B. Armstrong, Ann R. Kennedy, X. Steven Wan, Thomas H. Taylor, Quoc A. Nguyen, Jerald Jensen, Wayne Thompson, Westley Lagerberg and Frank L. Meyskens Jr.

Clin Cancer Res December 1 2000 6 (12) 4684-4691;
Clinical Trials

Pharmacokinetics of the Chemopreventive Agent Oltipraz and of Its Metabolite M3 in Human Subjects after a Single Oral Dose

Peter J. O’Dwyer, Christine Szarka, James M. Brennan, Paul B. Laub and James M. Gallo

Clin Cancer Res December 1 2000 6 (12) 4692-4696;
Clinical Trials

A Phase II Study of Razoxane, an Antiangiogenic Topoisomerase II Inhibitor, in Renal Cell Cancer with Assessment of Potential Surrogate Markers of Angiogenesis

Jeremy P. Braybrooke, Kenneth J. O’Byrne, David J. Propper, Andrew Blann, Mark Saunders, Nicola Dobbs, Cheng Han, Jane Woodhull, Karen Mitchell, Jeremy Crew, Kenneth Smith, Ross Stephens, Trivadi S. Ganesan, Denis C. Talbot and Adrian L. Harris

Clin Cancer Res December 1 2000 6 (12) 4697-4704;
Clinical Trials

Clinical Implications of Dihydropyrimidine Dehydrogenase (DPD) Deficiency in Patients with Severe 5-Fluorouracil-associated Toxicity: Identification of New Mutations in the DPD Gene

André B. P. van Kuilenburg, Janet Haasjes, Dick J. Richel, Lida Zoetekouw, Henk Van Lenthe, Ronney A. De Abreu, Jan G. Maring, Peter Vreken and Albert H. van Gennip

Clin Cancer Res December 1 2000 6 (12) 4705-4712;
Clinical Trials

White Blood Cell Count: A Prognostic Factor and Possible Subset Indicator of Optimal Treatment with Low-Dose Adjuvant Interferon in Primary Melanoma

Pauline de La Salmonière, Jean-Jacques Grob, Brigitte Dreno, Michèle Delaunay and Claude Chastang

Clin Cancer Res December 1 2000 6 (12) 4713-4718;
Clinical Trials

Phase I/II Study of G17-DT, an Anti-Gastrin Immunogen, in Advanced Colorectal Cancer

Andrew M. Smith, Timothy Justin, Dor Michaeli and Susan A. Watson

Clin Cancer Res December 1 2000 6 (12) 4719-4724;
Clinical Trials

Pharmacokinetics and Pharmacodynamics of the Novel Marine-derived Anticancer Agent Ecteinascidin 743 in a Phase I Dose-finding Study

Charlotte van Kesteren, Esteban Cvitkovic, Adelkrim Taamma, Luis López-Lázaro, Jośe M. Jimeno, Cecilia Guzman, Ron A. A. Mathôt, Jan H. M. Schellens, Jean-Louis Misset, Etienne Brain, Michael J. X. Hillebrand, Hilde Rosing and Jos H. Beijnen

Clin Cancer Res December 1 2000 6 (12) 4725-4732;
Clinical Trials

Multi-Institutional Validation Study of Carboplatin Dosing Formula Using Adjusted Serum Creatinine Level

Masahiko Ando, Hironobu Minami, Yuichi Ando, Hideo Saka, Shuzo Sakai, Masashi Yamamoto, Yasutsuna Sasaki, Kaoru Shimokata and Yoshinori Hasegawa

Clin Cancer Res December 1 2000 6 (12) 4733-4738;

Molecular Oncology, Markers, Clinical Correlates

Molecular Oncology, Markers, Clinical Correlates

Nitric Oxide Synthase, Cyclooxygenase 2, and Vascular Endothelial Growth Factor in the Angiogenesis of Non-Small Cell Lung Carcinoma

Aizen J. Marrogi, William D. Travis, Judith A. Welsh, Mohammed A. Khan, Haress Rahim, Henry Tazelaar, Peter Pairolero, Victor Trastek, James Jett, Neil E. Caporaso, Lance A. Liotta and Curtis C. Harris

Clin Cancer Res December 1 2000 6 (12) 4739-4744;
Molecular Oncology, Markers, Clinical Correlates

Relationship between c-erbB-2 and Other Tumor Characteristics in Breast Cancer Prognosis

Magali Ferrero-Poüs, Kamel Hacène, Cécile Bouchet, Viviane Le Doussal, Michèle Tubiana-Hulin and Frédérique Spyratos

Clin Cancer Res December 1 2000 6 (12) 4745-4754;
Molecular Oncology, Markers, Clinical Correlates

Spontaneous Apoptosis in Advanced Esophageal Carcinoma: Its Relation to Fas Expression

Muneaki Shibakita, Mitsuo Tachibana, Dipok K. Dhar, Satoshi Ohno, Hirofumi Kubota, Hiroshi Yoshimura, Shoichi Kinugasa, Reiko Masunaga and Naofumi Nagasue

Clin Cancer Res December 1 2000 6 (12) 4755-4759;
Molecular Oncology, Markers, Clinical Correlates

Detection of Epidermal Growth Factor Receptor in the Serum of Patients with Cervical Carcinoma

Min-Jeong Oh, Jin-Hyuk Choi, In Ho Kim, Yong Ho Lee, Joon Yong Huh, Yong Kyun Park, Kyu Wan Lee, Soo Yong Chough, Kap Soon Joo, Byung Sam Ku and Ho-Suk Saw

Clin Cancer Res December 1 2000 6 (12) 4760-4763;
Molecular Oncology, Markers, Clinical Correlates

PGP9.5 as a Prognostic Factor in Pancreatic Cancer

Ekmel Tezel, Kenji Hibi, Tetsuro Nagasaka and Akimasa Nakao

Clin Cancer Res December 1 2000 6 (12) 4764-4767;
Molecular Oncology, Markers, Clinical Correlates

Inducible Nitric Oxide Synthase and Nitrotyrosine in Human Metastatic Melanoma Tumors Correlate with Poor Survival

Suhendan Ekmekcioglu, Julie Ellerhorst, Christine M. Smid, Victor G. Prieto, Mark Munsell, Antonio C. Buzaid and Elizabeth A. Grimm

Clin Cancer Res December 1 2000 6 (12) 4768-4775;
Molecular Oncology, Markers, Clinical Correlates

Telomerase Activity in Soft-Tissue and Bone Sarcomas

Kenjiro Aogi, Anthony Woodman, Virginia Urquidi, David C. Mangham, David Tarin and Steve Goodison

Clin Cancer Res December 1 2000 6 (12) 4776-4781;
Molecular Oncology, Markers, Clinical Correlates

Loss of Heterozygosity and Microsatellite Instability as Predictive Markers for Neoadjuvant Treatment in Gastric Carcinoma

Tobias Grundei, Holger Vogelsang, Katja Ott, James Mueller, Michael Scholz, Karen Becker, Ulrich Fink, Jörg Rüdiger Siewert, Heinz Höfler and Gisela Keller

Clin Cancer Res December 1 2000 6 (12) 4782-4788;
Molecular Oncology, Markers, Clinical Correlates

Expression of E-cadherin and β-Catenin in Human Non-Small Cell Lung Cancer and the Clinical Significance

Shinichiro Kase, Kenji Sugio, Koji Yamazaki, Tatsuro Okamoto, Tokujiro Yano and Keizo Sugimachi

Clin Cancer Res December 1 2000 6 (12) 4789-4796;
Molecular Oncology, Markers, Clinical Correlates

Thymidylate Synthase Protein Expression in Primary Colorectal Cancer Compared with the Corresponding Distant Metastases and Relationship with the Clinical Response to 5-Fluorouracil

Carlo Aschele, Domizia Debernardis, Gianni Tunesi, Frank Maley and Alberto Sobrero

Clin Cancer Res December 1 2000 6 (12) 4797-4802;
Molecular Oncology, Markers, Clinical Correlates

Expression of the Human Telomerase Reverse Transcriptase Is Not Related to Telomerase Activity in Normal and Malignant Renal Tissue

Volker Rohde, Hans-Peter Sattler, Thorsten Bund, Helmut Bonkhoff, Thomas Fixemer, Christa Bachmann, Ramona Lensch, Gerhard Unteregger, Michael Stoeckle and Bernd Wullich

Clin Cancer Res December 1 2000 6 (12) 4803-4809;
Molecular Oncology, Markers, Clinical Correlates

A Genetic Epidemiological Study of Hereditary Prostate Cancer (HPC) in Finland: Frequent HPCX Linkage in Families with Late-onset Disease

Johanna Schleutker, Mika Matikainen, Jeffrey Smith, Pasi Koivisto, Agnes Baffoe-Bonnie, Tommi Kainu, Elizabeth Gillanders, Risto Sankila, Eero Pukkala, John Carpten, Dietrich Stephan, Teuvo Tammela, Michael Brownstein, Joan Bailey-Wilson, Jeffrey Trent and Olli-P. Kallioniemi

Clin Cancer Res December 1 2000 6 (12) 4810-4815;
Molecular Oncology, Markers, Clinical Correlates

p27^Kip1 Expression Is Associated with Clinical Outcome in Advanced Epithelial Ovarian Cancer: Multivariate Analysis

Valeria Masciullo, Gabriella Ferrandina, Bruna Pucci, Francesco Fanfani, Silvia Lovergine, Juan Palazzo, Gianfranco Zannoni, Salvatore Mancuso, Giovanni Scambia and Antonio Giordano

Clin Cancer Res December 1 2000 6 (12) 4816-4822;
Molecular Oncology, Markers, Clinical Correlates

Interstitial Collagenases as Markers of Tumor Progression

Constance E. Brinckerhoff, Joni L. Rutter and Ulrike Benbow

Clin Cancer Res December 1 2000 6 (12) 4823-4830;
Molecular Oncology, Markers, Clinical Correlates

Paucity of Functional T-Cell Memory to Melanoma Antigens in Healthy Donors and Melanoma Patients

Madhav V. Dhodapkar, James W. Young, Paul B. Chapman, William I. Cox, Jean Francois Fonteneau, Sebastian Amigorena, Alan N. Houghton, Ralph M. Steinman and Nina Bhardwaj

Clin Cancer Res December 1 2000 6 (12) 4831-4838;
Molecular Oncology, Markers, Clinical Correlates

Preferential Adhesion of Prostate Cancer Cells to Bone Is Mediated by Binding to Bone Marrow Endothelial Cells as Compared to Extracellular Matrix Components in Vitro

Carlton R. Cooper, Lisa McLean, Michael Walsh, Jeremy Taylor, Satoru Hayasaka, Jasmine Bhatia and Kenneth J. Pienta

Clin Cancer Res December 1 2000 6 (12) 4839-4847;
Molecular Oncology, Markers, Clinical Correlates

The Angiogenesis Inhibitor SU5416 Has Long-lasting Effects on Vascular Endothelial Growth Factor Receptor Phosphorylation and Function

Dirk B. Mendel, Randall E. Schreck, David C. West, Guangmin Li, Laurie M. Strawn, Sheila S. Tanciongco, Stefan Vasile, Laura K. Shawver and Julie M. Cherrington

Clin Cancer Res December 1 2000 6 (12) 4848-4858;
Molecular Oncology, Markers, Clinical Correlates

CDC25B and p53 Are Independently Implicated in Radiation Sensitivity for Human Esophageal Cancers

Hiroshi Miyata, Yuichiro Doki, Hitoshi Shiozaki, Msatoshi Inoue, Msahiko Yano, Yoshiyuki Fujiwara, Hirofumi Yamamoto, Kiyonori Nishioka, Kentaro Kishi and Morito Monden

Clin Cancer Res December 1 2000 6 (12) 4859-4865;
Molecular Oncology, Markers, Clinical Correlates

The Prognostic Value of Angiogenesis Factor Expression for Predicting Recurrence and Metastasis of Bladder Cancer after Neoadjuvant Chemotherapy and Radical Cystectomy

Keiji Inoue, Joel W. Slaton, Takashi Karashima, Chiaki Yoshikawa, Taro Shuin, Paul Sweeney, Randall Millikan and Colin P. N. Dinney

Clin Cancer Res December 1 2000 6 (12) 4866-4873;

Experimental Therapeutics, Preclinical Pharmacology

Experimental Therapeutics, Preclinical Pharmacology

Paclitaxel Enhances the Effects of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody ImClone C225 in Mice with Metastatic Human Bladder Transitional Cell Carcinoma

Keiji Inoue, Joel W. Slaton, Paul Perrotte, Darren W. Davis, Christiane J. Bruns, Daniel J. Hicklin, David J. McConkey, Paul Sweeney, Robert Radinsky and Colin P. N. Dinney

Clin Cancer Res December 1 2000 6 (12) 4874-4884;
Experimental Therapeutics, Preclinical Pharmacology

Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase

Francis M. Sirotnak, Maureen F. Zakowski, Vincent A. Miller, Howard I. Scher and Mark G. Kris

Clin Cancer Res December 1 2000 6 (12) 4885-4892;
Experimental Therapeutics, Preclinical Pharmacology

Cross-Resistance of Triphenylethylene-type Antiestrogens but not ICI 182,780 in Tamoxifen-stimulated Breast Tumors Grown in Athymic Mice

Eun Sook Lee, Jennifer MacGregor Schafer, Kathy Yao, Gale England, Ruth M. O’Regan, Alexander De Los Reyes and V. Craig Jordan

Clin Cancer Res December 1 2000 6 (12) 4893-4899;
Experimental Therapeutics, Preclinical Pharmacology

Cure of Metastatic Human Colonic Cancer in Mice with Radiolabeled Monoclonal Antibody Fragments

Thomas M. Behr, Rosalyn D. Blumenthal, Stavros Memtsoudis, Robert M. Sharkey, Stefan Gratz, Wolfgang Becker and David M. Goldenberg

Clin Cancer Res December 1 2000 6 (12) 4900-4907;
Experimental Therapeutics, Preclinical Pharmacology

Efficacy with a Replication-selective Adenovirus Plus Cisplatin-based Chemotherapy: Dependence on Sequencing but not p53 Functional Status or Route of Administration

Carla Heise, Marilyn Lemmon and David Kirn

Clin Cancer Res December 1 2000 6 (12) 4908-4914;
Experimental Therapeutics, Preclinical Pharmacology

Antisense of Human Peroxiredoxin II Enhances Radiation-induced Cell Death

Sun-Hee Park, Young Min Chung, Yong-Sik Lee, Hyung Jung Kim, Jun Suk Kim, Ho Zoon Chae and Young Do Yoo

Clin Cancer Res December 1 2000 6 (12) 4915-4920;
Experimental Therapeutics, Preclinical Pharmacology

In Vivo Targeting of Malignant Melanoma by ¹²⁵Iodine- and ^99mTechnetium-labeled Single-chain Fv Fragments against High Molecular Weight Melanoma-associated Antigen

Norbert Kang, Stephen Hamilton, Joy Odili, George Wilson and Jörg Kupsch

Clin Cancer Res December 1 2000 6 (12) 4921-4931;
Experimental Therapeutics, Preclinical Pharmacology

Response and Determinants of Sensitivity to Paclitaxel in Human Non-Small Cell Lung Cancer Tumors Heterotransplanted in Nude Mice

Roman Perez-Soler, Bonnie Kemp, Qing Ping Wu, Li Mao, Jorge Gomez, Anne Zeleniuch-Jacquotte, Herman Yee, Jin Soo Lee, Jaishree Jagirdar and Yi He Ling

Clin Cancer Res December 1 2000 6 (12) 4932-4938;
Experimental Therapeutics, Preclinical Pharmacology

Pegylated Liposome-encapsulated Doxorubicin and Cisplatin Enhance the Effect of Radiotherapy in a Tumor Xenograft Model

Kevin J. Harrington, Gail Rowlinson-Busza, Konstantinos N. Syrigos, Richard G. Vile, Paul S. Uster, A. Michael Peters and J. Simon W. Stewart

Clin Cancer Res December 1 2000 6 (12) 4939-4949;
Experimental Therapeutics, Preclinical Pharmacology

The Addition of Bryostatin 1 to Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) Chemotherapy Improves Response in a CHOP-resistant Human Diffuse Large Cell Lymphoma Xenograft Model

Ramzi M. Mohammad, Nathan R. Wall, Julie A. Dutcher and Ayad M. Al-Katib

Clin Cancer Res December 1 2000 6 (12) 4950-4956;

Cancer Biology, Immunology, Cytokines

Cancer Biology, Immunology, Cytokines

Arsenic Trioxide-mediated Cytotoxicity and Apoptosis in Prostate and Ovarian Carcinoma Cell Lines

Ruchan Uslu, Ulus Ali Sanli, Canfeza Sezgin, Bulent Karabulut, Ender Terzioglu, Serdar Bedii Omay and Erdem Goker

Clin Cancer Res December 1 2000 6 (12) 4957-4964;

Letter to the Editor

Letter to the Editor

Correspondence re: M. Kondo et al., Increased Expression of COX-2 in Nontumor Liver Tissue Is Associated with Shorter Disease-free Survival in Patients with Hepatocellular Carcinoma. Clin. Cancer Res., 5: 4005–4012, 1999.

Tohru Utsunomiya, Mitsuo Shimada, Tatsuya Rikimaru, Keizo Sugimachi, Ken-Ichi Ohkura, Shihoko Kaku, Koji Yamada and Ken-Ichi Taguchi

Clin Cancer Res December 1 2000 6 (12) 4965-4966;

Errata

Errata

Erratum/Correction

Clin Cancer Res December 1 2000 6 (12) 4967-4967;

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Table of Contents

The Biology Behind...

Editorials

Editorial

Advances in Brief

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Cancer Biology, Immunology, Cytokines

Letter to the Editor

Errata

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