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Experimental Therapeutics, Preclinical Pharmacology

Thresholds of O6-Alkylguanine-DNA Alkyltransferase which Confer Significant Resistance of Human Glial Tumor Xenografts to Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea or Temozolomide

Demetrius M. Kokkinakis, Dora B. Bocangel, S. Clifford Schold, Robert C. Moschel and Anthony E. Pegg
Demetrius M. Kokkinakis
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Dora B. Bocangel
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S. Clifford Schold
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Robert C. Moschel
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Anthony E. Pegg
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DOI:  Published February 2001
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Article Information

Volume 7, Issue 2, pp. 421-428

PubMed 
11234899

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 21, 2000
  • Revision received November 9, 2000
  • Accepted November 9, 2000
  • Published first February 1, 2001.

Copyright & Usage 
© 2001

Author Information

  1. Demetrius M. Kokkinakis2,
  2. Dora B. Bocangel,
  3. S. Clifford Schold,
  4. Robert C. Moschel, and
  5. Anthony E. Pegg
  1. Department of Neurosurgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-8855 [D. M. K.]; University of Texas Medical Branch, Sealy Center for Molecular Science, Galveston, Texas 77555 [D. B. B.]; National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201 [R. C. M.]; Departments of Cellular and Molecular Physiology and Pharmacology, Pennsylvania State University, College of Medicine, The Milton Hershey Medical Center, Hershey, Pennsylvania 17033 [A. E. P.]; and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 [S. C. S.]
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February 2001
Volume 7, Issue 2
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Thresholds of O6-Alkylguanine-DNA Alkyltransferase which Confer Significant Resistance of Human Glial Tumor Xenografts to Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea or Temozolomide
Demetrius M. Kokkinakis, Dora B. Bocangel, S. Clifford Schold, Robert C. Moschel and Anthony E. Pegg
Clin Cancer Res February 1 2001 (7) (2) 421-428;

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Thresholds of O6-Alkylguanine-DNA Alkyltransferase which Confer Significant Resistance of Human Glial Tumor Xenografts to Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea or Temozolomide
Demetrius M. Kokkinakis, Dora B. Bocangel, S. Clifford Schold, Robert C. Moschel and Anthony E. Pegg
Clin Cancer Res February 1 2001 (7) (2) 421-428;
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Clinical Cancer Research
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