Abstract
Data indicate that ultrahigh dose rate (>106 Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate that radiation fraction size, total dose, and number of fractions are critical parameters for FLASH-RT cognitive sparing without compromising tumor response.
See related article by Montay-Gruel et al., p. XXXX
Footnotes
Clin Cancer Res 2021;27:1–3
- Received November 5, 2020.
- Revision received November 18, 2020.
- Accepted November 30, 2020.
- Published first December 2, 2020.
- ©2020 American Association for Cancer Research.
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This OnlineFirst version was published on January 13, 2021
doi: 10.1158/1078-0432.CCR-20-4067
News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter
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