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CCR Translations

News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter

Christina C. Huang and Marc S. Mendonca
Christina C. Huang
1Department of Radiation Oncology, Indiana University School of Medicine, IUPUI, Indianapolis, Indiana.
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Marc S. Mendonca
1Department of Radiation Oncology, Indiana University School of Medicine, IUPUI, Indianapolis, Indiana.
2Department of Medical and Molecular Genetics, Indiana University School of Medicine, IUPUI, Indianapolis, Indiana.
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  • For correspondence: mmendonc@iupui.edu
DOI: 10.1158/1078-0432.CCR-20-4067
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Abstract

Data indicate that ultrahigh dose rate (>106 Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate that radiation fraction size, total dose, and number of fractions are critical parameters for FLASH-RT cognitive sparing without compromising tumor response.

See related article by Montay-Gruel et al., p. XXXX

Footnotes

  • Clin Cancer Res 2021;27:1–3

  • Received November 5, 2020.
  • Revision received November 18, 2020.
  • Accepted November 30, 2020.
  • Published first December 2, 2020.
  • ©2020 American Association for Cancer Research.

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This OnlineFirst version was published on January 13, 2021
doi: 10.1158/1078-0432.CCR-20-4067

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News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter
Christina C. Huang and Marc S. Mendonca
Clin Cancer Res January 13 2021 DOI: 10.1158/1078-0432.CCR-20-4067

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News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter
Christina C. Huang and Marc S. Mendonca
Clin Cancer Res January 13 2021 DOI: 10.1158/1078-0432.CCR-20-4067
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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