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CCR Translations

New Insights into the Molecular Profile of Penile Squamous Cell Carcinoma

Bradley A. McGregor and Guru P. Sonpavde
Bradley A. McGregor
Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
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  • ORCID record for Bradley A. McGregor
Guru P. Sonpavde
Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: gurup_sonpavde@dfci.harvard.edu
DOI: 10.1158/1078-0432.CCR-21-0139
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Abstract

Genomic alterations in penile squamous cell carcinoma (PSCC) appear similar to squamous cell carcinomas of the head and neck and esophagus but not lung, skin, bladder, and cervix. PSCCs display genomic heterogeneity, low mutation burden, and potentially actionable alterations in the Notch, DNA repair, kinase, and cell-cycle pathways.

See related article by Chahoud et al., p. 2560

Footnotes

  • Clin Cancer Res 2021;27:1–3

  • Received January 26, 2021.
  • Revision received February 12, 2021.
  • Accepted February 19, 2021.
  • Published first March 2, 2021.
  • ©2021 American Association for Cancer Research.
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This OnlineFirst version was published on April 7, 2021
doi: 10.1158/1078-0432.CCR-21-0139

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New Insights into the Molecular Profile of Penile Squamous Cell Carcinoma
Bradley A. McGregor and Guru P. Sonpavde
Clin Cancer Res April 7 2021 DOI: 10.1158/1078-0432.CCR-21-0139

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New Insights into the Molecular Profile of Penile Squamous Cell Carcinoma
Bradley A. McGregor and Guru P. Sonpavde
Clin Cancer Res April 7 2021 DOI: 10.1158/1078-0432.CCR-21-0139
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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