Abstract
Genomic alterations in penile squamous cell carcinoma (PSCC) appear similar to squamous cell carcinomas of the head and neck and esophagus but not lung, skin, bladder, and cervix. PSCCs display genomic heterogeneity, low mutation burden, and potentially actionable alterations in the Notch, DNA repair, kinase, and cell-cycle pathways.
See related article by Chahoud et al., p. 2560
Footnotes
Clin Cancer Res 2021;27:1–3
- Received January 26, 2021.
- Revision received February 12, 2021.
- Accepted February 19, 2021.
- Published first March 2, 2021.
- ©2021 American Association for Cancer Research.
This OnlineFirst version was published on April 7, 2021
doi: 10.1158/1078-0432.CCR-21-0139
New Insights into the Molecular Profile of Penile Squamous Cell Carcinoma
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