RT Journal Article
SR Electronic
T1 Toward Concurrent Testing for Somatic and Germline Variants in Cancer Patients
JF Clinical Cancer Research
JO Clin Cancer Res
FD American Association for Cancer Research
SP 3987
OP 3988
DO 10.1158/1078-0432.CCR-16-1043
VO 22
IS 16
A1 Mandelker, Diana
YR 2016
UL http://clincancerres.aacrjournals.org/content/22/16/3987.abstract
AB Sequencing for somatic alterations in patients' tumors is being increasingly clinically implemented to detect mutations that may guide therapy. Germline analysis of a cohort of patients undergoing tumor sequencing with matched normal has revealed that a small but significant percentage of these patients have germline variants that confer cancer susceptibility. Clin Cancer Res; 22(16); 3987–8. ©2016 AACR.See related article by Seifert et al., p. 4087