RT Journal Article
SR Electronic
T1 Interleukin-12 Message in a Bottle
JF Clinical Cancer Research
JO Clin Cancer Res
FD American Association for Cancer Research
SP 6080
OP 6082
DO 10.1158/1078-0432.CCR-20-3250
VO 26
IS 23
A1 Cirella, Assunta
A1 Berraondo, Pedro
A1 Di Trani, Claudia Augusta
A1 Melero, Ignacio
YR 2020
UL http://clincancerres.aacrjournals.org/content/26/23/6080.abstract
AB IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.See related article by Hewitt et al., p. 6284