PT  - JOURNAL ARTICLE
AU  - Megyesi, Joseph F.
AU  - Kachur, Edward
AU  - Lee, Donald H.
AU  - Zlatescu, Magdalena C.
AU  - Betensky, Rebecca A.
AU  - Forsyth, Peter A.
AU  - Okada, Yoshifumi
AU  - Sasaki, Hikaru
AU  - Mizoguchi, Masahiro
AU  - Louis, David N.
AU  - Cairncross, J. Gregory
TI  - Imaging Correlates of Molecular Signatures in Oligodendrogliomas
AID  - 10.1158/1078-0432.CCR-04-0209
DP  - 2004 Jul 01
TA  - Clinical Cancer Research
PG  - 4303--4306
VI  - 10
IP  - 13
4099  - http://clincancerres.aacrjournals.org/content/10/13/4303.short
4100  - http://clincancerres.aacrjournals.org/content/10/13/4303.full
SO  - Clin Cancer Res2004 Jul 01; 10
AB  - Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T1 images and mixed intensity signal on T1 and T2. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.