RT Journal Article
SR Electronic
T1 Aurora Kinases: New Targets for Cancer Therapy
JF Clinical Cancer Research
JO Clin Cancer Res
FD American Association for Cancer Research
SP 6869
OP 6875
DO 10.1158/1078-0432.CCR-06-1405
VO 12
IS 23
A1 Carvajal, Richard D.
A1 Tse, Archie
A1 Schwartz, Gary K.
YR 2006
UL http://clincancerres.aacrjournals.org/content/12/23/6869.abstract
AB The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase inhibition in the treatment of cancer.