RT Journal Article
SR Electronic
T1 Clinical Significance of Serum Mesothelin in Patients with Mesothelioma and Lung Cancer
JF Clinical Cancer Research
JO Clin Cancer Res
FD American Association for Cancer Research
SP 5076
OP 5081
DO 10.1158/1078-0432.CCR-07-0629
VO 13
IS 17
A1 Cristaudo, Alfonso
A1 Foddis, Rudy
A1 Vivaldi, Agnese
A1 Guglielmi, Giovanni
A1 Dipalma, Nicola
A1 Filiberti, Rosangela
A1 Neri, Monica
A1 Ceppi, Marcello
A1 Paganuzzi, Michela
A1 Ivaldi, Gian Paolo
A1 Mencoboni, Manlio
A1 Canessa, Pier Aldo
A1 Ambrosino, Nicolino
A1 Chella, Antonio
A1 Mutti, Luciano
A1 Puntoni, Riccardo
YR 2007
UL http://clincancerres.aacrjournals.org/content/13/17/5076.abstract
AB Purpose: High levels of serum-soluble mesothelin family proteins (SMRP) have been found to be associated with malignant mesothelioma (MM), but not lung cancer (LC). To verify the clinical role of this marker for both these tumors, we tested serum SMRP in the largest population of thoracic cancers ever assembled. Experimental Design: SMRP blood concentrations were measured in 107 patients with MM, 215 patients with LC, 130 patients with benign respiratory diseases (BRD), and 262 controls. Statistical comparison between mean serum SMRP levels in all groups was done and receiver operating characteristic curves were constructed to evaluate the performance of this marker. Results: SMRP levels were significantly higher in patients with MM and LC than in patients with benign respiratory diseases and controls (P < 0.001). The area under the receiver operating characteristic curve for serum SMRP discriminating MM and controls was 0.77 (95% confidence interval, 0.71-0.83), with a best cutoff of 1.00 nmol/L (sensitivity, 68.2%; specificity, 80.5%). In both MM and LC, serum SMRP levels did not differ significantly between early and late stages. High SMRP levels proved to be an independent negative prognostic factor in patients with MM. Conclusions: Our data confirm that serum SMRP is a promising marker for the diagnosis, prognosis, and clinical monitoring of MM. We found that serum SMRP dosage may prove helpful in LC diagnosis as well. These data may also have positive repercussions on secondary preventive medical strategies for workers previously exposed to asbestos.