RT Journal Article
SR Electronic
T1 Immunostimulation Versus Immunosuppression after Multiple Vaccinations: the Woes of Therapeutic Vaccine Development
JF Clinical Cancer Research
JO Clin Cancer Res
FD American Association for Cancer Research
SP 6745
OP 6747
DO 10.1158/1078-0432.CCR-09-2377
VO 15
IS 22
A1 Eggermont, Alexander M.M.
YR 2009
UL http://clincancerres.aacrjournals.org/content/15/22/6745.abstract
AB Three articles in this issue of Clinical Cancer Research show how multiple vaccinations can lead to immunosuppression. Moreover, two studies in patients show that granulocyte macrophage colony-stimulating factor (GM-CSF) as an adjuvant immunostimulant to different kind of vaccines can lead to adverse outcome in terms of relapse-free and overall survival. Modulation of regulatory T-cell activity may be required to overcome this outcome and may be crucial for the successful development of therapeutic vaccines. (Clin Cancer Res 2009;15(22):6745–7)