RT Journal Article
SR Electronic
T1 Stearoyl Co-A Desaturase 1 as a ccRCC Therapeutic Target: Death by Stress
JF Clinical Cancer Research
JO Clin Cancer Res
FD American Association for Cancer Research
SP 3111
OP 3113
DO 10.1158/1078-0432.CCR-13-0800
VO 19
IS 12
A1 Leung, Janet Y.
A1 Kim, William Y.
YR 2013
UL http://clincancerres.aacrjournals.org/content/19/12/3111.abstract
AB There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC. Clin Cancer Res; 19(12); 3111–3. ©2013 AACR.See related article by von Roemeling et al., Clin Cancer Res, vol. 19(9), p. 2368–80