Table 2

Time for the PC-3 human xenografts to grow to 16-fold their original weight, and other parameters regarding the effect and toxicity of the NLCQ-1 ± CPM treatmenta

Treatment groupMedian time (days)Tumor growth delay (days)Log killOptimal % T/Cb (day)Max % Relative Mean Net Wt Loss (day)
Control (vehicle)c20.52.0 (12)
CPM
 80 mg/kg (QD× 4)d37.316.81.339 (21)13.6 (17)
 54 mg/kg (QD× 4)26.96.40.2543 (21)no wt loss
 36 mg/kg (QD× 4)24.23.7−0.0362 (21)6.1 (12)
NLCQ-1: 10 mg/kg (QD× 4)23.42.9−0.1173 (21)no wt loss
NLCQ-1+ 80 mg/kg CPM38.918.41.499 (28)10.2 (12)
NLCQ-1+ 54 mg/kg CPM27.67.10.3227 (21)1.2 (31)
NLCQ-1+ 36 mg/kg CPM32.912.40.8728 (21)8.3 (31)
  • a Data reprinted with permission (44) .

  • b T and C are median tumor weights of treated and control groups, respectively, on each observation day.

  • c Saline.

  • d Treatment was initiated on day 10 post xenograft inoculation. Both drugs were given i.p. in saline. In the combination treatment, NLCQ-1 was given 1.5 h before CPM. QD × 4, per day for 4 days.