Table 1

Effect of chemotherapy on neurologic parameters in young rats

GroupaSNCVb (mean ± SD)NGFc (ng/ml)
Daym/sec
Controls3541.1 ± 3.069.4 ± 12.7
Cisplatin3527.8 ± 1.942.7 ± 7.1d
Cisplatin + ALC3533.4 ± 2.8e58.1 ± 15.3
Controls1233.0 ± 1.4
Paclitaxel1227.5 ± 0.6
Paclitaxel + ALC1231.2 ± 1.1f
  • a Cisplatin: 2 mg/kg i.p., twice a week for 4 weeks from day 1; ALC: 100 mg/kg p.o., daily, starting 5 days before and ending the day of the last drug treatment; paclitaxel: 5 mg/kg i.v., on days 1, 2, 3, 9, and 10. Controls were treated with the drug solvent.

  • b SNCV in the tail nerve.

  • c Nerve Growth Factor level in rat plasma. Mean ± SD are reported.

  • d P < 0.05 versus controls.

  • e P < 0.01 versus controls.

  • f P < 0.001 compared with the corresponding drug-treated group.