Table 2

PK parameters of mesna regimens

PK parameters of mesna, urine, iv/oral/oral
Ucum0–12 (μmol)Ucum0–24 (μmol)Ucum0–24 (%)Rmax (μmol/h)tmid, max (h)Rmin (μmol/h)tmid, min (h)CLren (l/h·kg)
Day 1
 No.13131313131313ne
 Median 3589.99 4424.2618.98 570.686.9  27.6523.0
 Minimum 1641.43 1866.7910.15 198.210.8  10.3322.5
 Maximum 4878.72 6987.2225.691115.9611.0 110.2323.2
 Meangeo 3340.90 4204.8118.21 526.77  30.78
 95% CIln 2786.73 3395.6815.39 412.62  19.88
 * 4005.27 5206.7321.55 672.50  47.68
Day 5
 No.1313131313131313
 Median 4229.26 5505.8726.69 664.997.1  44.3923.00.116
 Minimum 3199.56 3383.7514.03 448.710.8   5.9222.50.047
 Maximum12558.5917405.5564.012694.3411.0 138.3323.10.328
 Meangeo 4796.54 5903.5525.57 753.693.2  31.8622.90.128
 95% CIln 3806.53 4566.4220.11 557.941.6  17.1422.80.084
 * 6044.04 7632.2232.511018.106.6  59.2123.00.194
Ratio day 5 vs. day 1 (ANOVA)
 Estimate1.441.401.431.04
90% CIa1.24–1.661.21–1.641.21–1.690.63–1.70
Day 1: ratio i.v.:oral:oral vs. i.v.:i.v.:i.v. (ANOVA)
 Estimate1.011.230.827.45
 90% CI0.89–1.141.08–1.390.71–0.964.31–12.89
Day 5: ratio i.v.:oral:oral vs. i.v.:i.v.:i.v. (ANOVA)
 Estimate1.441.711.294.811.13
 90% CI1.28–1.631.50–1.941.11–1.502.78–8.330.95–1.35
  • a CI, confidence interval.