Table 4

PK parameters of ifosfamide in plasma

Ratio i.v.:oral:oral vs. i.v.:i.v.:i.v. (ANOVA)
Cmax (μmol/l)t1/2 (h)AUC0–12 (μmol·h/liter)AUC0–24 (μmol·h/liter)AUC (μmol·h/liter)CL (liter/h·kg)Vz (liter/kg)MRTss, 2h-infus (h)
Estimate1.001.001.001.001.001.000.981.02
90% CI0.91–1.100.95–1.050.92–1.090.93–1.080.93–1.080.92–1.070.90–1.070.98–1.06