Table 1

Patient characteristics at baseline

ParameterCohort 1 (n = 16)Cohort 2 (n = 16)
Mean age, years (range)49.7 (34–67)55.4 (25–66)
HER2 status (n)
 IHC 2+70
 IHC 3+916
ERa status (n)
 Positive126
 Negative47
 Unknown03
Disease stage (n)
 IIIB64
 IV1012
Median no. of metastatic sites (range)2 (2–6)3 (1–6)
Disease site (n)
 Regional node1010
 Bone74
 Lung63
 Liver51
 Malignant pleural effusion51
 Distant node17
 Skin18
Previous therapy (n)
 Chemotherapy23
 Hormonal12
 Radiotherapy24
  • a ER, estrogen receptor.