Table 3

Pharmacokinetic data for doxorubicin and paclitaxel and their metabolites

DrugAUCCmaxt1/2
Without TaWith TPWithout TWith TPWithout TWith TP
Doxorubicin1.291.440.103.373.860.2443.1133.800.09
Doxorubicinol0.410.460.04b0.030.040.2447.8440.750.16
7-Deoxy-13-dihydro-doxorubicinone0.160.240.0001b0.010.020.03b19.7921.520.77
Paclitaxel13.4913.130.714.464.210.4920.7921.20.90
6-α Hydroxyl paclitaxel0.91.00.40.420.460.461.591.820.71
  • a T, trastuzumab.

  • b Significant difference.