Table 1

Correlation of PSMAa expression status with clinical parameters and disease outcome in 136 cases of prostate cancer treated by radical prostatectomy

Clinical parameter/disease outcomePSMA expression status (no. of patients)Significance (P)
Nonoverexpressingb (71)Overexpressingc (65)
Mean preoperative PSA (ng/ml)9.10 ± 5.9118.28 ± 17.700.006
Mean tumor Gleason score5.92 ± 1.206.33 ± 1.210.04
Mean DNA index (diploid = 1.00)1.03 ± 0.331.32 ± 0.500.002
Advanced tumor stage (III/IV)23/71 (32%)33/65 (51%)0.029
Recurrent disease20/71 (28%)37/65 (57%)0.001
Mean time to recurrence (mo)43.7534.780.001
  • a PSMA, prostate-specific membrane antigen; PSA, prostate-specific antigen.

  • b Low staining intensity.

  • c High staining intensity.