Table 2

Univariate and multivariate analyses of clinical and laboratory variables and progression-free survival in 77 patients with medulloblastoma

VariableaUnivariate analysisMultivariate analysis
Hazard ratio(95% CIb)PHazard ratio(95% CI)P
Caspase-8 expression3.161.44–6.970.0042.601.11–6.100.03
Caspase-9 expression1.580.73–3.460.25
Age2.361.14–4.910.022.140.88–5.260.10
Metastatic stage2.141.00–4.590.051.530.65–3.630.33
Sex1.870.80–4.360.152.040.83–5.050.12
Surgery1.670.78–3.580.191.930.80–4.660.15
Therapy1.310.54–3.210.551.250.43–3.660.69
Apoptosis index0.630.27–1.450.280.710.32–1.560.39
  • a The variables were compared as follows: caspase-8 expression, weak versus moderate/strong; caspase-9 expression, weak versus moderate/strong; age, <3 years versus ≥3 years; metastatic stage, M1–3 versus M0; sex, male versus female; surgery, extent of resection <90% versus ≥90%; therapy, local radiation therapy or chemotherapy alone versus local radiation therapy plus chemotherapy; apoptosis index, high versus low.

  • b CI, confidence interval.