Table 2

BRAF mutations in different stages of melanoma tumor progression

No. of primary tumorsRGPVGPaMetastasis
7Val599GluVal599GluVal599Glub
1Val599ArgVal599Arg c
  • a Four of the primary tumors were subjected to laser-capture microdissection and consisted of a pure vertical growth phase. The remaining four tumors were manually dissected and, therefore, also included the radial growth phase.

  • b Metastases were available for analysis from six of the seven primary tumors.

  • c No metastases were available for analysis.