Baseline and peak cytokine concentrations after the first s.c. administration of rHuIL-12
| 0.1 μg/kg (n = 3) | 0.5 μg/kg (n = 19) | 1 μg/kg (n = 4) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Peak | Baseline | Peak | Baseline | Peak | ||||||||||||||||
| Median | Range | Median | Range | Median | Range | Median | Range | Median | Range | Median | Range | ||||||||||
| IL-12 (pg/ml) | <50 | <50 | <50a | 298g | 116–830 | <50 | 548 | 475–2630 | |||||||||||||
| IFN-γ (IU/ml) | <0.03 | <0.03–0.4 | 2.6h | 1.4–2.9 | <0.03 | <0.03–1.4 | 13g | 1.5–41 | 0.4 | <0.03–0.5 | 55 | 12–184 | |||||||||
| IL-10 (pg/ml) | <1b | 15 | <1c | <1–6 | 22g | 4–49 | <1 | 37h | 27–81 | ||||||||||||
| TNF-α (pg/ml) | 26 | 21–40 | 84h | 73–108 | 25 | 8–83 | 95g | 60–143 | 25 | 7–33 | 168h | 149–223 | |||||||||
| IL-8 (pg/ml) | 5 | <1–15 | 24 | 11–53 | 11d | <1–35 | 38h | 14–223 | <1 | <1–8 | 53h | 32–87 | |||||||||
| IL-6 (pg/ml) | 6e | <2–10 | 25 | 22–27 | 16f | <2–79 | 82g | 17–280 | <2 | 83h | 42–137 | ||||||||||
As described in “Results,” induction of the various cytokines did not occur in all patients. Only data from patients with increments of cytokine concentrations post-IL-12 in comparison with baseline are shown. Symbols denote numbers of patients in which increments of cytokine concentrations have been observed.
a n = 10.
b n = 1.
c n = 13.
d n = 14.
e n = 2.
f n = 16.
g P < 0.001; paired comparison between peak and baseline levels.
h P < 0.05.