Table 1

Baseline and peak cytokine concentrations after the first s.c. administration of rHuIL-12

0.1 μg/kg (n = 3)0.5 μg/kg (n = 19)1 μg/kg (n = 4)
BaselinePeakBaselinePeakBaselinePeak
MedianRangeMedianRangeMedianRangeMedianRangeMedianRangeMedianRange
IL-12 (pg/ml)<50<50<50a298g116–830<50548475–2630
IFN-γ (IU/ml)<0.03<0.03–0.42.6h1.4–2.9<0.03<0.03–1.413g1.5–410.4<0.03–0.55512–184
IL-10 (pg/ml)<1b15<1c<1–622g 4–49<137h27–81 
TNF-α (pg/ml)2621–4084h73–108258–8395g 60–143257–33168h149–223 
IL-8 (pg/ml)5<1–152411–5311d<1–3538h 14–223<1<1–853h32–87 
IL-6 (pg/ml)6e<2–102522–2716f<2–7982g 17–280<283h42–137
  • As described in “Results,” induction of the various cytokines did not occur in all patients. Only data from patients with increments of cytokine concentrations post-IL-12 in comparison with baseline are shown. Symbols denote numbers of patients in which increments of cytokine concentrations have been observed.

  • a n = 10.

  • b n = 1.

  • c n = 13.

  • d n = 14.

  • e n = 2.

  • f n = 16.

  • g P < 0.001; paired comparison between peak and baseline levels.

  • h P < 0.05.