Table 2

Leucocyte subsets after the first s.c. injection of rHuIL-12

	0.1 μg/kg (n = 3)							0.5 μg/kg (n = 15)							1 μg/kg (n = 4)
		Baseline cell count^a			Nadir^a			Baseline cell count^a			Nadir^a			Baseline cell count^a			Nadir^a
		Median	Range	Median	Range	Median	Range	Median	Range	Median	Range	Median	Range
Lymphocytes	1.8	1.5–1.9	0.8^b	0.5–0.8	1.3	0.5–2.9	0.5^b	0.1–1.1	1.4	1.0–2.3	0.3^c	0.2–0.5
Neutrophils	4.0	3.5–4.1	0.9		4.2	2.7–6.8	1.5^b	0.7–4.7	3.7	2.9–5.3	1.4^c	1.1–1.7
Monocytes	0.53	0.46–0.66	0.21	0.17–0.38	0.30	0.17–0.58	0.15^b	0.03–0.43	0.35	0.29–0.5	0.11^c	0.02–0.16

^a Absolute numbers are expressed as (number of cells × 10⁹/liter).
^b P < 0.001; paired comparisons between nadirs and baseline counts.
^c P < 0.05.