Table 2

Leucocyte subsets after the first s.c. injection of rHuIL-12

0.1 μg/kg (n = 3)0.5 μg/kg (n = 15)1 μg/kg (n = 4)
Baseline cell countaNadiraBaseline cell countaNadiraBaseline cell countaNadira
MedianRangeMedianRangeMedianRangeMedianRangeMedianRangeMedianRange
Lymphocytes1.81.5–1.90.8b0.5–0.81.30.5–2.90.5b0.1–1.11.41.0–2.30.3c0.2–0.5
Neutrophils4.03.5–4.10.94.22.7–6.81.5b0.7–4.73.72.9–5.31.4c1.1–1.7
Monocytes0.530.46–0.660.210.17–0.380.300.17–0.580.15b0.03–0.430.350.29–0.50.11c0.02–0.16
  • a Absolute numbers are expressed as (number of cells × 109/liter).

  • b P < 0.001; paired comparisons between nadirs and baseline counts.

  • c P < 0.05.