Table 1

Main PK parameters of imatinib in CML patients on day 1 of treatment

PatientDisease phaseDose (mg)Tmaxa (h)Cmax (μg/ml)bAUC (μg/ml h)ct1/2 (h)
001BC40024.3532.997.3
002BC40013.2927.8015.2
0503AP40031.0813.2014.2
0502AP40022.8934.0011.4
0501AP40011.5318.0012.8
001/udineAP4001.53.1840.4012.7
00213CP40021.3315.1013.1
00241CP40021.1715.8013.5
Mean2.35224.6612.5
95% CI1.058.502.4
0504AP60036.2182.6013.7
002/udineAP60046.1987.7013.5
003BC60014.8044.9010.6
004BC600412.15158.9012.8
003/udineAP60039.82124.5811.4
Mean7.8399.7412.5
95% CI3.8054.151.4
  • a Tmax indicates the time (h) to peak concentrations.

  • b Cmax values were obtained from experimental data.

  • c AUCs were calculated by trapezoidal rule.