Table 4

Imatinib distribution in murine organs

Tumor-bearing nude mice were treated with imatinib (160 mg/kg) with or without CLI (350 mg/kg) p.o. Two h after dosing, animals were killed and organs extracted.

OrganImatinib (160 mg/kg)Imatinib (160 mg/kg) + CLI (350 mg/kg)P
Mean (μg/g)95% CIMean (μg/g)95% CI
Liver49.6±18.7101.3±35.6<0.01
Spleen74.5±24.3132.3±44.1<0.01
Kidney49.3±17.6100.8±41.50.01
Intestine49.1±24.169.7±26.50.06
Tumor30.3±10.857.8±13.70.03