Table 1

Associations between genotype of BRCA2 polymorphisms and breast cancer risk according to menopausal status

GenotypeCases n (%)Controls n (%)ORa (95% CI)ORb (95% CI)
N/H372c
 All
  A1/A197 (65)95 (62)1.01.0
  A1/A247 (32)56 (36)0.82 (0.51–1.33)0.79 (0.48–1.30)
  A2/A25 (3)3 (2)1.60 (0.37–6.91)1.65 (0.36–7.58)
 Premenopausals
  A1/A150 (67)38 (61)1.01.0
  A1/A224 (32)21 (34)0.89 (0.43–1.84)0.74 (0.33–1.65)
  A2/A21 (1)3 (5)0.25 (0.02–2.46)0.22 (0.02–2.32)
 Postmenopausals
  A1/A147 (64)57 (62)1.01.0
  A1/A223 (31)35 (38)0.80 (0.41–1.56)0.64 (0.30–1.34)
  A2/A24 (5)0 (0)
M/V784d
 All
  A1/A1118 (79)134 (87)1.01.0
  A1/A231 (21)20 (13)1.78 (0.96–3.29)2.03 (1.07–3.87)
  A2/A20 (0)0 (0)
 Premenopausals
  A1/A157 (76)54 (87)1.01.0
  A1/A218 (24)8 (13)2.12 (0.85–5.28)2.22 (0.82–5.96)
  A2/A20 (0)0 (0)
 Postmenopausals
  A1/A161 (82)80 (87)1.01.0
  A1/A213 (18)12 (13)1.54 (0.64–3.71)1.90 (0.75–4.83)
  A2/A20 (0)0 (0)
  • a Adjusted for age.

  • b Adjusted for age, first-degree family history of breast cancer, age at first live birth, and body mass index.

  • c N/H372: A1 allele (N372); A2 allele (H372).

  • d M/V784: A1 allele (M784); A2 allele (V784).