Immunohistochemical analysis of GEO colon cancer xenografts after treatment with ZD6474 and paclitaxel
| Treatment | Tumor volume (cm3) | Ki67 (% positive cells) | TGF-α (% positive cells) | bFGF (% positive cells) | VEGF (% positive cells) | Factor VIII-related antigen (MVCs) |
|---|---|---|---|---|---|---|
| Control | 1.45 (±0.2) | 70 (±5) | 70 (±5) | 65 (±4) | 70 (±8) | 18 (±2) |
| ZD6474 (25 mg/kg) | 0.38 (±0.05) | 50 (±8) | 55 (±6) | 45 (±5) | 50 (±7) | 9 (±2) |
| ZD6474 (50 mg/kg) | 0.24 (±0.05) | 40 (±5) | 40 (±6) | 30 (±5) | 35 (±3) | 6 (±2) |
| ZD6474 (100 mg/kg) | 0.15 (±0.03) | 25 (±5) | 35 (±6) | 25 (±3) | 20 (±4) | 1 (±1) |
| ZD6474 (150 mg/kg) | 0.05 (±0.01) | 20 (±5) | 25 (±4) | 15 (±5) | 10 (±3) | 1 (±1) |
| Paclitaxel (400 μg) | 0.65 (±0.1) | 50 (±7) | 65 (±5) | 60 (±5) | 60 (±6) | 15 (±3) |
| Paclitaxel (400 μg) + ZD6474 (25 mg/kg) | 0.10 (±0.02) | 30 (±5) | 20 (±6) | 10 (±4) | 10 (±5) | 3 (±1) |
| Paclitaxel (400 μg) + ZD6474 (50 mg/kg) | 0.05 (±0.02) | 25 (±4) | 15 (±2) | 10 (±3) | 5 (±1) | 1 (±1) |