Table 2

Immunohistochemical analysis of GEO colon cancer xenografts after treatment with ZD6474 and paclitaxel

TreatmentTumor volume (cm3)Ki67 (% positive cells)TGF-α (% positive cells)bFGF (% positive cells)VEGF (% positive cells)Factor VIII-related antigen (MVCs)
Control1.45 (±0.2)70 (±5)70 (±5)65 (±4)70 (±8)18 (±2)
ZD6474 (25 mg/kg)0.38 (±0.05)50 (±8)55 (±6)45 (±5)50 (±7)9 (±2)
ZD6474 (50 mg/kg)0.24 (±0.05)40 (±5)40 (±6)30 (±5)35 (±3)6 (±2)
ZD6474 (100 mg/kg)0.15 (±0.03)25 (±5)35 (±6)25 (±3)20 (±4)1 (±1)
ZD6474 (150 mg/kg)0.05 (±0.01)20 (±5)25 (±4)15 (±5)10 (±3)1 (±1)
Paclitaxel (400 μg)0.65 (±0.1)50 (±7)65 (±5)60 (±5)60 (±6)15 (±3)
Paclitaxel (400 μg) + ZD6474 (25 mg/kg)0.10 (±0.02)30 (±5)20 (±6)10 (±4)10 (±5)3 (±1)
Paclitaxel (400 μg) + ZD6474 (50 mg/kg)0.05 (±0.02)25 (±4)15 (±2)10 (±3)5 (±1)1 (±1)