Antitumor activity of ZD6474 alone or in combination with paclitaxel on GEO human colon cancer xenografts
| Treatment | Average tumor volume on day 28 after tumor cell injection (cm3) | Average time (days) to reach a tumor volume of ∼2 cm3 |
|---|---|---|
| Control | 1.95 (±0.15) | 28 (±3) |
| Paclitaxel | 0.95 (±0.1) | 42 (±3) |
| ZD6474 (25 mg/kg) | 0.48 (±0.1) | 44 (±2) |
| ZD6474 (50 mg/kg) | 0.26 (±0.1) | 50 (±4) |
| ZD6474 (100 mg/kg) | 0.1 (±0.05) | 57 (±2) |
| ZD6474 (150 mg/kg) | 0.03 (±0.01) | 66 (±4) |
| Paclitaxel + ZD6474 (25 mg/kg) | 0.22 (±0.1) | 65 (±3) |
| Paclitaxel + ZD6474 (50 mg/kg) | 0.03 (±0.01) | 76 (±5) |
| Paclitaxel + ZD6474 (100 mg/kg) | 0.01 (±0.01) | 86 (±4)a |
| Paclitaxel + ZD6474 (150 mg/kg) | 0.01 (±0.01) | 108 (±6)b |
a Two of 10 mice were without histologic evidence of GEO tumors at this time point.
b Four of 10 mice were without histologic evidence of GEO tumors at this time point.