Table 3

Antitumor activity of ZD6474 alone or in combination with paclitaxel on GEO human colon cancer xenografts

TreatmentAverage tumor volume on day 28 after tumor cell injection (cm3)Average time (days) to reach a tumor volume of ∼2 cm3
Control1.95 (±0.15)28 (±3)
Paclitaxel0.95 (±0.1)42 (±3)
ZD6474 (25 mg/kg)0.48 (±0.1)44 (±2)
ZD6474 (50 mg/kg)0.26 (±0.1)50 (±4)
ZD6474 (100 mg/kg)0.1 (±0.05)57 (±2)
ZD6474 (150 mg/kg)0.03 (±0.01)66 (±4)
Paclitaxel + ZD6474 (25 mg/kg)0.22 (±0.1)65 (±3)
Paclitaxel + ZD6474 (50 mg/kg)0.03 (±0.01)76 (±5)
Paclitaxel + ZD6474 (100 mg/kg)0.01 (±0.01)86 (±4)a
Paclitaxel + ZD6474 (150 mg/kg)0.01 (±0.01)108 (±6)b
  • a Two of 10 mice were without histologic evidence of GEO tumors at this time point.

  • b Four of 10 mice were without histologic evidence of GEO tumors at this time point.