Table 5

Mean pharmacokinetic parameters of sibrotuzumab measured by ELISA

Dose group (mg/m2)nCmin(ss) (μg/ml)Cmax(ss) (μg/ml)CL (ml/h)Vca (liter)Vss (liter)t1/2αa (h)t1/2β (day)AUC (μg∗h/ml)AUCβ (%)
57Mean0.07792.5386.33.901.36105
SD0.0610.3821.70.780.2934.9
106Mean0.3435.0787.84.831.76275
SD0.2721.4153.91.970.41119
256Mean1.6112.865.44.525.4610.12.6292994.4
SD0.601.2151.131.4012.10.8285.311.4
507Mean7.7331.041.93.855.4716.64.86261090.4
SD5.145.6160.4191.3610.12.5297111.2
  • a Not available for subjects who exhibited one-compartment kinetics.