Table 2

Distribution of molecular abnormalities according to histological grade of preinvasive bronchial lesions

LesionsP53P16INK4Cyclin D1Cyclin EBBR < 1a
Metaplasia3% (1/31)12% (3/25)6% (2/31)3% (1/31)3% (1/31)
MD50% (6/12)017% (2/12)25% (3/12)25% (3/12)
MD33% (3/9)22% (2/9)67% (6/9)33% (3/9)67% (6/9)
SD78% (7/9)14% (1/7)56% (5/9)55% (5/9)78% (7/9)
CIS63% (12/19)47% (8/17)53% (10/19)89% (17/19)53% (10/19)
Pa P < 0.001P < 0.01P < 0.001P < 0.001P < 0.001
  • a P, probability of difference in distribution between low-grade (metaplasia and MD) and high-grade lesions (MD, SD, and CIS; Fisher’s exact test).