Table 3

Hepatic transaminase elevations and hyperbilirubinemia occurring on study (n = 73 courses)a

Squalamine dose level (mg/m2/day)ASTALTBilirubin
Grade 1–2Grade 3Grade 3 > 5 days or grade 4Grade 1–2Grade 3Grade 3 > 5 days or grade 4Grade 1–2Grade 3Grade 4
6100000000
12100000000
24020200000
34000000000
47.6000000000
66.64000000000
93000000000
130000000000
182000000000
255211311400
357530620000
500832604201
700420411102
  • a Values represent the number of courses in which transaminase elevations or hyperbilirubinemia occurred. No distinction was made for causality.