Table 4

Noncompartmental pharmacokinetic parameters for squalaminea

Dose level (mg/m2/day)No. of patientsCmax (μg/ml)Css (μg/ml)CL (liters/h/m2)Vz (liters/m2)t1/2 (h)AUC0–∞ (μg·h/ml)
610.760.350.881.190.9435.04
1210.770.351.2726.8414.6347.17
2430.64 (32%)0.48 (20%)2.23 (18%)8.65 (66%)2.85 (67%)54.89 (18%)
3410.910.901.8017.386.6994.07
47.614.971.220.8442.2534.77224.89
66.6412.031.541.6014.376.23208.13
9312.172.082.0319.876.77229.18
130111.803.451.2824.4613.25508.15
18216.565.211.4233.9516.60641.83
25568.02 (28%)6.20 (45%)3.65 (99%)60.56 (158%)7.49 (80%)747.18 (34%)
357610.22 (34%)8.63 (43%)4.65 (66%)54.08 (103%)7.19 (72%)1,109.20 (33%)
500720.65 (26%)17.72 (33%)2.72 (95%)42.39 (87%)11.04 (62%)2,153.79 (26%)
700316.1014.432.1338.5712.571645.32
Mean332.67 (85%)36.84 (124%)9.46 (81%)
  • a Values represent mean [CV (%)] for all patients who completed the entire 5-day squalamine infusion (n = 26). Vz, terminal volume; AUC0–∞, area under the time-concentration curve from zero extrapolated to infinity.