Table 2

Tissue distribution of selected PARP-1 inhibitors

Tissue:plasma ratios were calculated from distribution data (as described in Fig. 4<$REFLINK> ) after i.p. administration of NU1085 (40 mg/kg), BZ5, TI1, and TI3 (50 mg/kg).

TimeTissueTissue:Plasma ratio
NU1085BZ5TI1TI3
30 minBrain0.0101.51.8
Tumor0.11.01.21.0
Liver2.35.63.93.9
60 minBrain0.0302.12.1
Tumor0.341.52.41.7
Liver2.95.26.65.2