Table 1

In vivo activity of CDDO and CDDO-Im in L1210 murine leukemia

Animals received i.p. injection with 10 million cultured L1210 cells on day 0 and were treated as described in Fig. 6A<$REFLINK> . Total L1210 cells were harvested from the peritoneal cavity and counted. Statistical analysis was performed by t test, and the Ps indicate significance compared with control animals.

Treatment group (μg/day)nMean no. of cells recovered (millions)P
Control (vehicle)9124 ± 63
CDDO (100)524 ± 45<0.01
CDDO-Im (100)512 ± 9<0.01