Table 1

Characteristics of CRC patients in the two treatment cohorts

Feature (n)Surgery (%)Surgery + 5-FU (%)P
Total (206)103103
Mean age (yrs)61.460.40.48
Mean follow-up (mo)44.347.90.54
Year of surgery
 1985–1989 (17)170
 1990–1994 (106)5848
 1995–1999 (83)2855<0.01
Sex
 Female (74)37 (50)37 (50)
 Male (132)66 (50)66 (50)1.0
Site
 Rectum (49)24 (49)25 (51)
 Distal colon (47)24 (51)23 (49)
 Proximal (110)55 (50)55 (50)1.0
Histological grade
 Well/moderate (162)78 (48)84 (52)
 Poor (41)23 (56)18 (44)0.36
Nodal involvement
 1 or 2 nodes (96)44 (46)52 (54)
 ≥3 nodes (110)59 (54)51 (46)0.26
p53
 Wild-type (110)51 (46)59 (54)
 Mutant (76)43 (57)33 (43)0.17
MSI
 − (165)79 (48)86 (52)
 + (28)12 (43)16 (57)0.62
CIMP
 − (139)65 (47)74 (53)
 + (67)38 (57)29 (43)0.18