Table 1

Influence of irofulven, ET-743, or cisplatin on the viability of multidrug resistant cells

HL-60HL-60/Vinc (P-gp)HL-60/Adr (MRP)Resistance level (P-gp)Resistance level (MRP)
Vincristine (ng/ml)0.65900ND1385ND
Adriamycin (ng/ml)5.4ND1184ND221
Irofulven (ng/ml)3053855031.31.6
Cisplatin (ng/ml)3104003051.31.0
ET-743 (pg/ml)400107001700274.3