Table 1

Correlation between biallelic inactivation of the LKB1 gene and LKB1 protein expression as determined by immunohistochemistrya

CaseLKBI
Biallelic gene inactivationProtein expression
1YesNegative
2YesNegative
3YesNegative
4YesPositive
5YesNegative
6YesNegative
7NoPositive
8NoPositive
9NoPositive
10NoPositive
11NoPositive
12NoPositive
13NoPositive
14NoPositive
15NoPositive
16NoPositive
17NoPositive
18NoPositive
19NoPositive
20NoPositive
21NoPositive
  • a Biallelic inactivation as evidenced by loss of heterozygosity for microsatellite markers near the LKB1 locus, coupled with an LKB1 non-sense mutation or promoter hypermethylation as reported previously.