Table 4

Diagnosis of CC cells in HCC at various disease extents

GroupNo. of casesNo. of positive cases (%)
hTERT mRNAAFP mRNA
Existence of HCC
 HCC (−)400 (0%)P = 1.9 × 10−90 (0%)P = 0.019
 HCC (+)5529 (53%)8 (15%)
Modified TNMa
 T182 (25%)P = 0.00680 (0%)P = 0.13
 T2175 (29%)1 (6%)
 T3 and T4a159 (60%)2 (13%)
 T4b76 (86%)2 (29%)
 M187 (88%)3 (38%)
Criteria by Milan Group (Ref. 29 )
 Meets criteria257 (28%)P = 0.00111 (4%)P = 0.059
 Does not meet criteria3022 (73%)7 (23%)
Intrahepatic metastasis
 Negative216 (29%)P = 0.00620 (8%)P = 0.018
 Positive3423 (68%)8 (24%)
  • a Modified TNM staging classification by American Liver Tumor Study Group (Ref. 28 ).