Table 2

Selected up-regulated gene products in malignant HNSC vs. normal mucosaa

GenBank accession no.Gene nameFunction
AF016098Vascular endothelial cell growth factor 165 receptor 2Angiogenesis
AF024710VEGFAngiogenesis
U09278Fibroblast activation proteinAngiogenesis
M63193Platelet-derived endothelial cell growth factorAngiogenesis
AF024710VEGFAngiogenesis
AF024710VEGFAngiogenesis
M63193Platelet-derived endothelial cell growth factorAngiogenesis
L22475Bax γApoptosis
AF016266TRAIL receptor 2Apoptosis
U50062RIP protein kinaseApoptosis
X07820Metalloproteinase stromelysin-2Cell adhesion
X63629p cadherinCell adhesion
D21255OB-cadherin-2Cell adhesion
D21254OB-cadherin-1Cell adhesion
L23808Human metalloproteinaseCell adhesion
X53586Integrin α 6Cell adhesion
U37022Cyclin-dependent kinase 4Cell cycle
X51688Cyclin ACell cycle
X00588Epidermal growth factor receptorCytokine
X06374Platelet-derived growth factorCytokine
M38449Transforming growth factor-βCytokine
M34539FK506-binding proteinCytokine modulation
X63547tre oncogeneDegradation
U09759JNK2MAP kinase pathway
U12779MAP kinase-activated protein kinase 2MAP kinase pathway
U25265MEK5MAP kinase pathway
X53416Actin-binding protein (filamin)Structural
M13509Human skin collagenaseStructural
D7857714-3-3 proteinTranscription
M29039jun-BTranscriptional regulation
V00568c-mycTranscriptional regulation
L37882Frizzledwnt pathway
AF003837Jagged1wnt pathway
U95299Human Notch4wnt pathway
U81787Wnt10Bwnt pathway
U07563ABL
  • a TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; JNK, c-Jun NH2-terminal kinase; MEK, MAP/extracellular signal-regulated kinase kinase; ABL, Abelson; RIP, receptor interacting protein.