Table 3

Summary of pharmacokinetic parameters (n = 65)

ParameterMean ± SDRange
Irinotecan
 CL lactone (liter/h)73.0 ± 19.931.1–109
 AUC lactone (μg·h/ml)5.73 ± 0.8564.05–8.04
 AUC total (μg·h/ml)20.5 ± 7.0710.4–46.1
SN-38
 CL(m)a lactone (liter/h)1,260 ± 690300–3,330
 AUC total (μg·h/ml)0.637 ± 0.3360.216–1.75
SN-38G
 AUC total (μg·h/ml)b4.46 ± 4.670.962–30.0
APC
 AUC total (μg·h/ml)c4.57 ± 4.021.12–14.0
AUC ratios
 SN-38/CPT-110.032 ± 0.0150.014–0.088
 SN-38G/SN-38b7.60 ± 5.881.70–37.5
 APC/CPT-11c0.21 ± 0.150.035–0.53
  • a CL(m), metabolic clearance.

  • b n = 53.

  • c n = 12; fewer patients were studied because of a lack of sufficient material for repeat analyses.