Table 3

Pharmacokinetic parameters of free EGCG obtained after p.o. administration of EGCG or Polyphenon E before and after 4 weeks of green tea polyphenol treatment

800 mg EGCG (n = 7)a800 mg EGCG as Polyphenon E (n = 8)400 mg EGCG (n = 8)400 mg EGCG as Polyphenon E (n = 8)
First doseOn the last treatment dayFirst doseOn the last treatment dayFirst doseOn the last treatment dayFirst doseOn the last treatment day
AUCb (min·μg/ml)95.6 ± 46.8c145.6 ± 85.1d98.1 ± 46.5158.4 ± 89.8d46.9 ± 21.443.9 ± 25.6e,f71.2 ± 36.954.8 ± 23.7e
Cmax (ng/ml)234.9 ± 140.9390.3 ± 231.4263.8 ± 135.7287.6 ± 124.2137.6 ± 66.5161.4 ± 100.5f179.9 ± 114.3155.4 ± 61.9f
Tmax (min)224.4 ± 33.4210.0 ± 73.5112.5 ± 65.6248.5 ± 184.9183.9 ± 117.1135.6 ± 48.4150.8 ± 109.7146.6 ± 102.2
CL/F (liter/min)10.5 ± 4.47.3 ± 3.49.6 ± 3.48.0 ± 7.111.2 ± 5.213.1 ± 8.67.0 ± 3.49.0 ± 4.2
Vβ/F (liter)1910 ± 8661686 ± 12412760 ± 19011551 ± 7952516 ± 7503456 ± 32002139 ± 7163759 ± 2089
t1/2 (min)136.7 ± 54.4158.9 ± 78.7200.4 ± 94.7163.0 ± 56.2183.0 ± 75.3170.5 ± 50.2241.2 ± 115.6296.6 ± 152.9
  • a Data from only 7 subjects were used in the analysis because of incomplete sample collection in 1 study participant.

  • b AUC0–∞ was calculated after the first catechin dose. After repeated dosing, AUC0–24h was calculated after administration of 800-mg dose of the study agent on the last treatment day, and AUC0–12h was calculated after administration of 400-mg dose of the study agent on the last treatment day.

  • c Mean ± SD.

  • d Significantly different from that of the first dose, P < 0.05.

  • e Significantly different from that after 800-mg dose of EGCG as Polyphenon E on the last treatment day, P < 0.05.

  • f Significantly different from that after 800-mg dose of EGCG on the last treatment day, P < 0.05.