Table 4

AUCa (μg·min/ml) of total (free and conjugated) EGC and EC obtained after p.o. administration of Polyphenon E before and after 4 weeks of Polyphenon E treatment

800 mg EGCG as Polyphenon E (n = 8)400 mg EGCG as Polyphenon E (n = 8)
First doseAfter repeated dosingFirst doseAfter repeated dosing
Total EGC103.4 ± 41.4b95.9 ± 16.250.4 ± 19.1c63.6 ± 47.2
Total EC130.4 ± 72.2154.5 ± 37.655.4 ± 16.6c77.8 ± 81.5
  • a AUC0–∞ was calculated after the first catechin dose. After repeated dosing, AUC0–24h was calculated after administration of 800-mg dose of Polyphenon E on the last treatment day, and AUC0–12h was calculated after administration of 400-mg dose of Polyphenon E on the last treatment day.

  • b Mean ± SD.

  • c Significantly different from that at the 800-mg dose level, P < 0.05.