Table 1

Number (percentage) of melanocytic tumors demonstrating membrane-associated and cytoplasmic localization of β-catenin

Type of melanomasLesionNumber examinedMembranous localizationaCytoplasmic localizationa
0<5%5–50%>50%0<5%5–50%>50%
SuperficialPrimary1062 (2)9 (9)45 (42)50 (47)5 (5)4 (4)21 (20)76 (71)
Metastatic321 (3)7 (22)11 (34)13 (41)8 (25)6 (19)10 (31)8 (25)
NodularPrimary581 (2)8 (14)21 (36)28 (48)9 (16)5 (8)22 (38)22 (38)
Metastatic341 (3)4 (12)9 (26)20 (59)10 (30)1 (3)9 (26)14 (41)
Benign nevi72 (29)5 (71)2 (29)5 (71)
  • a Scored as percentage of positively stained cells.