Relevant cellular functions enriched among genes overexpressed in anti-VEGF treatment–resistant pancreatic cancer cell lines versus their respective treatment-sensitive control cell lines
| Genes overexpressed | P | Cellular functions | |
|---|---|---|---|
| FGBR vs. COLO357FG | P1BR vs. PANC-1 | ||
| CXCL10, IL8, PF4 | CCL2, IL8 | 3.21E-02 | Mobilization of myeloid progenitor cells |
| C5, CCL5, CXCL1, CXCL3, CXCL10, DEFB4A, IL8, IL15, IL1B, PF4, TGFB1, TLR4 | CCL2, CXCL1, CXCL3, IL8, IL1B, TLR4 | 4.44E-02 | Attraction of leukocytes |
| C5, CCL5, CXCL1, CXCL3, CXCL10, IL8, PF4, TGFB1 | CXCL1, CXCL3, IL8 | 7.59E-03 | Attraction of neutrophils |
| C5, CCL5, CCL26 (includes EG:10344), IL8, PLAUR | CCL2, CCL26 (includes EG:10344), IL8 | 1.79E-02 | Chemotaxis of basophils |
| IFNAR1, BDNF, CAST, IL8, TFF | IL8, TFF1 | 3.61E-02 | Chemokinesis of eukaryotic cells |