Table 1.

Relevant cellular functions enriched among genes overexpressed in anti-VEGF treatment–resistant pancreatic cancer cell lines versus their respective treatment-sensitive control cell lines

Genes overexpressedPCellular functions
FGBR vs. COLO357FGP1BR vs. PANC-1
CXCL10, IL8, PF4CCL2, IL83.21E-02Mobilization of myeloid progenitor cells
C5, CCL5, CXCL1, CXCL3, CXCL10, DEFB4A, IL8, IL15, IL1B, PF4, TGFB1, TLR4CCL2, CXCL1, CXCL3, IL8, IL1B, TLR44.44E-02Attraction of leukocytes
C5, CCL5, CXCL1, CXCL3, CXCL10, IL8, PF4, TGFB1CXCL1, CXCL3, IL87.59E-03Attraction of neutrophils
C5, CCL5, CCL26 (includes EG:10344), IL8, PLAURCCL2, CCL26 (includes EG:10344), IL81.79E-02Chemotaxis of basophils
IFNAR1, BDNF, CAST, IL8, TFFIL8, TFF13.61E-02Chemokinesis of eukaryotic cells