Table 1.

Clinical and laboratory features of untreated CLL patients

CLL patientSexAgeRai stageDT, moCytogenetic abnormalities (FISH)aZAP70bp53 status
1M7101617p−, Tri12Highwt
2M672>617p−Highwt
3F62211q−, 13q−Highwt
4M6842Tri12Highwt
5M682>611q−Highwt
6M612317p−Highwt
7M591Tri12Highwt
8F782511q−Highwt
9F701Tri12Highwt
10M744>1213q−Highwt
11F54217p−, 13q−Highwt
12F661Tri12Highwt
13M583<1211q−, Tri12Highwt
14M65114NormalLowwt
15F641<611q−, Tri12qLowwt
16M62418NaLowwt
17M6207211q−Lowwt
18M51037NormalLowwt
19F5933NormalLowwt
20F65313q−, Tri12Lowwt
21M57160Tri12Lowwt
22M692>613q−, 17p−Lowwt
23M604117p−Lowwt
24F640NormalHighwt
25M70113q−Lowwt
26M630>1213q−Lowwt
27F68113q−Lowwt
28M442117p−, 13q−Highmut (exon 5)
29M62017p−, 13q-Highmut (exon 7)
30M56117p−Highmut (exon 5)
31M692217p−Lowmut (exon 7)
32F8216013q−Lowmut (exon 5)
33F59217p−, 13q−Lowmut (exon 8)
34F68417p−NAmut (exon 6)
35M620NaNAwt

Abbreviations: mut, mutated; wt, wild-type; NA, not available.

  • aFISH defects were found using a B-CLL FISH panel.

  • bZAP70 expression was determined by Western blot analysis.