Toxicities
| Adverse event | Grade 3 | % | Grade 4 | % |
|---|---|---|---|---|
| Constitutional | ||||
| Fatigue | 1 | 5.6 | 0 | 0.0 |
| Hematologic | ||||
| Neutropenia | 4 | 22.2 | 5 | 27.8 |
| Leukopenia | 3 | 16.7 | 3 | 16.7 |
| Anemia | 1 | 5.6 | 0 | 0 |
| Thrombocytopenia | 1 | 5.6 | 2 | 11.1 |
| Nonhematologic | ||||
| Cough | 1 | 5.6 | 0 | 0 |
| Hypocalcemia | 1 | 5.6 | 0 | 0 |
| Hypophosphatemia | 1 | 5.6 | 0 | 0 |
| Hyponatremia | 2 | 11.1 | 0 | 0 |
| Hypokalemia | 1 | 5.6 | 0 | 0 |
| Nausea | 1 | 5.6 | 0 | 0 |
| Vomiting | 1 | 5.6 | 0 | 0 |
| Infection | 2 | 11.1 | 0 | 0 |
| DVT | 1 | 5.6 | 0 | 0 |
| Dysphagia | 1 | 5.6 | 0 | 0 |
NOTE. Of note, 8/18 patients (44.4%) did not experience significant (>grade 2) toxicity. Patients were assessed on day 1 of every 21-day cycle for changes in performance status and the presence of toxicities. Toxicities were graded according to CTCAE Version 3.0.