Table 5.

Kaplan–Meier estimates of survival by HPV status as defined by each test

Mean, moSE95% CIP
 LowerUpper
Disease-specific survival
RNA qPCR
 HPV negative26.71.723.330.10.005
 HPV positive34.91.132.737.0 
p16 IHC
 HPV negative27.21.923.630.90.018
 HPV positive33.51.430.736.2 
HR HPV ISH
 HPV negative27.61.824.131.00.02
 HPV positive34.01.331.436.7 
p16 IHC/HR HPV ISH
 HPV negative27.71.724.331.10.027
 HPV positive33.91.431.236.7 
DNA qPCR
 HPV negative26.11.922.529.90.008
 HPV positive33.81.331.326.2
DNA qPCR/p16 IHC
 HPV negative26.71.923.030.40.005
 HPV positive34.91.032.937.0
RNA qPCR/p16 IHC
 HPV negative26.81.923.030.60.007
 HPV positive34.91.132.737.0
Combined DNA/RNA qPCR
 HPV negative26.71.723.330.10.006
 HPV positive34.81.132.637.1 
Overall survival
RNA qPCR
 HPV negative24.71.821.228.20.003
 HPV positive33.81.530.936.7 
P16 IHC
 HPV negative25.71.921.929.50.021
 HPV positive31.81.728.535.2 
HR HPV ISH
 HPV negative25.71.822.229.30.011
 HPV positive33.01.629.836.2 
p16 IHC/HR HPV ISH
 HPV negative25.91.822.429.50.016
 HPV positive32.91.729.536.2
DNA qPCR
 HPV negative24.41.920.728.00.007
 HPV positive32.11.628.935.3
DNA qPCR/p16 IHC
 HPV negative24.81.921.028.60.002
 HPV positive33.91.421.036.7 
RNA qPCR/p16 IHC
 HPV negative24.82.021.028.70.003
 HPV positive33.81.530.936.7
Combined DNA/RNA qPCR
 HPV negative26.71.821.228.20.004
 HPV positive33.71.520.730.1