Table 1.

Clinicopathologic characteristics of patients included in the study

CharacteristicNormal colonic tissue patients (n = 20)Sporadic MSI (n = 33)Lynch syndrome (n = 35)PaMSS (n = 19)Pb
Age, mean (SD)64.4 (15.8)65.3 (12.6)47.5 (11.7)<0.000167.1 (12.0)0.629
Sex, n (%)
 Males10 (50)16 (48.5)19 (54.3)0.8088 (42.1)0.775
 Females10 (50)17 (51.5)16 (45.7)11 (57.9)
Tumor location,cn (%)
 Proximal26 (78.8)20 (57.1)0.1465 (26.3)<0.0001
 Distal5 (15.2)11 (31.4)14 (73.7)
 Unknown2 (6)4 (11.4)
Tumor stage, n (%)
 I2 (6)8 (22.9)0.0653 (15.8)0.334
 II15 (45.5)11 (31.4)9 (47.4)
 III7 (21.2)9 (25.7)6 (31.6)
 IV7 (21.2)2 (5.7)1 (5.2)
 Unknown2 (6)5 (14.3)
MMR protein expression, n (%)
 Loss of MLH131 (93)17 (48.6)0.0001
 Loss of MSH214 (40)
 Loss of MSH64 (11.4)
 Normal expression2 (7)19 (100)
  • aP value for the comparison of sporadic MSI versus Lynch syndrome.

  • bP value for the comparison of sporadic MSI versus MSS.

  • cRelative to the splenic flexure.