Table 4.

Characteristics of HPV-positive versus HPV-negative cases

HPV status by RNA qPCR analysisTotalStatistical significance
 NegativePositive
Patient/tumor data
 No. of patients61 (64%)34 (36%)95 (100%)
Age at diagnosis, y
 Mean60.853.30.003
 SEM1.41.7
Sex
 Female16 (26%)6 (18%)22 (23%)NS
 Male45 (74%)28 (82%)73 (77%)
Tumor site
 Tonsil30 (49%)22 (65%)52 (55%)
 Soft palate13 (21%)4 (12%)17 (18%)NS
 Base of tongue11 (18%)6 (18%)17 (18%)
 Oropharynx (not further specified)7 (11%)2 (6%)9 (9%)
Nodal stage
 N015 (31%)9 (28%)24 (30%)
 N1 without ECS8 (16%)3 (9%)11 (13%)NS
 N2/3 or N1 with ECS26 (53%)20 (63%)46 (57%)
 Total49 (100%)32 (100%)81 (100%)
Smoking
Nonsmoker8 (16%)13 (42%)21 (26%)
 <20 pack-year history16 (31%)11 (36%)27 (33%)0.007
 ≥20 pack-year history27 (53%)7 (23%)34 (42%)
 Total51 (100%)31 (100%)82 (100%)
Alcohol consumption
 Nondrinker6 (14%)5 (16%)11 (14%)
 <28 units/wk14 (33%)18 (56%)32 (43%)NS
 ≥28 units/wk23 (53%)9 (28%)32 (43%)
 Total43 (100%)32 (100%)75 (100%)