Table 1.

Patient characteristics with 3-year PFS and OS by category

Characteristic# Pts3-year PFS ± SE (%)P3-year OS ± SE (%)P
Overall626.1 ± 3.4N/A19.1 ± 5.7N/A
Gender
 Male395.3 ± 3.60.908720.5 ± 7.40.7101
 Female236.5 ± 6.316.1 ± 8.5
Treatment and patient age
≤18 years old: 2,475 mg/m2/d divided TID564.8 ± 3.30.39815.0 ± 5.60.2755
>18 years old: 1,800 mg/m2/d divided BID616.7 ± 15.250.0 ± 20.4
Stratum
 Stratum 1: ≥ 1 measurable lesion on CT or MRI388.1 ± 5.50.560316.0 ± 6.50.7827
 Stratum 2: BM tumor ± ≥1 MIBG avid site244.2 ± 4.124.5 ± 10.6
Tumor sites at study entry
 Bone marrow only400.021100.0913
 MIBG only616.7 ± 15.240.0 ± 21.9
 CT/MRI only400
 BM, MIBG1400.021823.1 ± 14.30.0072
 BM, CT/MRI200
 CT/MRI, MIBG1315.4 ± 10.038.5 ± 13.5
 BM, MIBG, CT/MRI1900
Relapse/recurrence prior to study entry
 Yes522.0 ± 1.90.000510.5 ± 5.00.0026
 No1026.7 ± 16.163.5 ± 17.2
Prior hematopoietic stem cell transplanta
 Yes517.4 ± 4.10.423121.3 ± 6.70.4834
 No6020.0 ± 17.9
Prior retinoid therapya
 Yes444.5 ± 3.10.058314.9 ± 6.20.1683
 No1312.5 ± 11.753.6 ± 18.3
  • aFive patients with missing data. Pts = patients.